Symbicort is a prescription combination inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD). It contains a corticosteroid to reduce airway inflammation and a long-acting bronchodilator to relax airway muscles, improving breathing. Used daily as maintenance therapy, Symbicort helps prevent asthma attacks and COPD flare-ups but is not intended for sudden breathing issues. It must be used exactly as prescribed and not for acute shortness of breath—use a rescue inhaler instead. Rinse your mouth with water after each use to help prevent oral thrush.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Symbicort is a prescription combination inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD). It contains a corticosteroid to reduce airway inflammation and a long-acting bronchodilator to relax airway muscles, improving breathing. Used daily as maintenance therapy, Symbicort helps prevent asthma attacks and COPD flare-ups but is not intended for sudden breathing issues. It must be used exactly as prescribed and not for acute shortness of breath—use a rescue inhaler instead. Rinse your mouth with water after each use to help prevent oral thrush.
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Important safety information
Symbicort (budesonide/formoterol) is widely regarded as a safe and effective treatment for patients with asthma and chronic obstructive pulmonary disease (COPD). However, there are specific medical conditions and sensitivities where its use may pose a risk.
While not absolute contraindications, the following conditions warrant careful assessment and monitoring before and during Symbicort use:
By maintaining open communication with their healthcare team, patients can use Symbicort safely and effectively while minimizing potential risks and ensuring optimal respiratory control.
Albuterol is a prescription bronchodilator that helps open the airways in the lungs. Albuterol is used to prevent and treat bronchospasm in people with asthma, chronic obstructive pulmonary disease (COPD), and other breathing disorders. It works quickly by relaxing the muscles around the airways, often providing relief within minutes during asthma attacks or episodes of sudden shortness of breath. It is available by prescription only in several forms, including metered-dose inhalers (such as ProAir HFA), nebulizer solutions (such as AccuNeb), and tablets.
Budesonide is a prescription corticosteroid used as a daily maintenance treatment to prevent and control asthma symptoms in adults and children. By reducing airway inflammation and swelling, it improves breathing and helps prevent asthma attacks. It is available as a dry powder inhaler and as a nebulizer suspension for those who have difficulty using inhalers. Budesonide must be used consistently as prescribed, even when symptoms are absent. After each use, rinse your mouth with water to help prevent oral thrush, a common side effect.
Fluticasone propionate is a corticosteroid nasal spray used to treat nasal congestion, sneezing, and a runny or itchy nose caused by seasonal, perennial, or nonallergic rhinitis. It works by reducing inflammation in the nasal passages to relieve allergy symptoms at their source. While not a decongestant, consistent daily use typically controls symptoms within several days.
Fluticasone propionate is the generic version of Flovent HFA and Flovent Diskus, an inhaled corticosteroid used every day to prevent asthma symptoms in adults and children 4 years and older. It calms inflammation in the airways so they are less sensitive, less swollen, and less likely to tighten up. We carry the Prasco authorized generic in both the HFA metered-dose inhaler (44, 110, and 220 mcg) and the Diskus dry powder inhaler (50, 100, and 250 mcg). It is a maintenance medicine, not a rescue inhaler, and is available by prescription only.
Fluticasone propionate and Salmeterol is a prescription inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines a corticosteroid to reduce airway inflammation and a long-acting beta₂-agonist (LABA) to relax airway muscles, helping to prevent wheezing, coughing, and shortness of breath. It is taken regularly, usually twice daily, for long-term symptom control and is not a rescue inhaler.
Hydroxyzine hydrochloride is a prescription antihistamine used to treat a range of conditions, including anxiety, allergic reactions, itching (pruritus), and nausea, as well as for sedation before or after medical procedures. By acting on the central nervous system, hydroxyzine produces calming and sedative effects while also blocking histamine-related symptoms such as itching and hives. It is often prescribed for short-term or intermittent use, particularly when non-sedating treatments are ineffective or inappropriate.
Symbicort is a combination inhaler containing budesonide and formoterol, prescribed to help control respiratory conditions such as asthma and COPD. Budesonide is an anti-inflammatory corticosteroid that reduces swelling and irritation in the airways, while formoterol is a bronchodilator that relaxes airway muscles to enhance airflow and ease breathing.
Together, the two components of Symbicort offer a dual therapeutic approach. By addressing both inflammation and constriction, Symbicort provides comprehensive management for individuals with persistent asthma or COPD.
Patients need to understand that while one component (budesonide) is a steroid, the medication as a whole is not simply a steroid treatment. It is a strategic combination designed to keep airways open consistently. This dual-action mechanism makes Symbicort effective for chronic management.
Note: This medication’s generic and brand-name formulations are used interchangeably throughout this article.
Budesonide is a synthetic corticosteroid (glucocorticoid) medication that helps reduce inflammation in the body. It works by binding to glucocorticoid receptors in cells and suppressing the release of inflammatory chemicals such as cytokines and prostaglandins. This action decreases swelling, irritation, and mucus production in affected tissues.
Medically, budesonide is used to treat various inflammatory and allergic conditions. Inhaled forms (like Pulmicort) are prescribed for asthma and chronic obstructive pulmonary disease (COPD), nasal sprays for allergic rhinitis or nasal polyps, and oral or rectal forms for inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
Because of its strong local anti-inflammatory effect and relatively low systemic absorption, budesonide often causes fewer side effects than other corticosteroids when used correctly.
Formoterol is a long-acting beta-agonist (LABA) bronchodilator used to help improve breathing in respiratory conditions such as asthma and COPD. It works by stimulating beta-2 receptors on the smooth muscle lining the airways, relaxing the smooth muscle. This leads to bronchodilation—wider air passages that make it easier for air to flow in and out of the lungs.
Formoterol has a rapid onset of action—often within minutes—along with a long duration of action, lasting up to 12 hours. This makes it useful for both maintenance therapy and ongoing symptom prevention. Because LABAs do not treat underlying inflammation, formoterol is most commonly used in combination with an inhaled corticosteroid like budesonide.
Symbicort is primarily used for the long-term treatment of asthma and COPD (Chronic Obstructive Pulmonary Disease). It is essential for preventing symptoms such as wheezing, coughing, shortness of breath, and chest tightness.
Unlike some inhalers, Symbicort is not suitable for immediate relief during sudden asthma attacks or acute COPD exacerbations. Instead, it’s prescribed to manage respiratory conditions consistently over time.
Symbicort operates through the synergistic action of budesonide and formoterol. Budesonide, a corticosteroid, effectively reduces inflammation in the respiratory tract, thereby reducing swelling and irritation over time.
This action helps alleviate symptoms such as persistent coughing and breathing difficulties associated with chronic respiratory diseases.
While the bronchodilator formoterol starts working relatively quickly, improving breathing within approximately 15 minutes, the steroid budesonide requires continuous use to reduce inflammation effectively.
Patients often notice gradual improvements in symptoms, such as reduced wheezing and easier breathing, with ongoing Symbicort treatment. Full symptom relief and improvement in lung function may take one to two weeks of consistent use.
Symbicort should not be used for sudden-onset symptoms due to the systemic effects and budesonide’s onset time. The medication’s design encourages consistent use for preventive respiratory care.
Symbicort is delivered via a metered-dose inhaler, and proper technique is essential to ensure the medication reaches the airways effectively.
Most patients are prescribed two inhalations twice daily, ideally taken at the exact times each day to maintain consistent therapeutic levels. This regular schedule supports ongoing symptom control and helps prevent asthma or COPD flare-ups.
Before use, the inhaler should be shaken well, and patients should exhale fully before placing the mouthpiece between their lips. After pressing down to release a dose, patients should inhale deeply and hold their breath for several seconds to ensure full absorption.
Rinsing the mouth afterward is recommended to decrease the risk of irritation or oral thrush associated with inhaled corticosteroids. Patients should not exceed the prescribed number of inhalations and should consult their provider if symptoms worsen or if the rescue inhaler is needed more frequently than usual.
Proper Device Care (Priming Required): Symbicort must be primed before first use by shaking for 5 seconds and by spraying 4 test sprays away from the face; re-priming with 2 sprays is required if unused for more than 7 days or if dropped; failure to prime can result in inconsistent or inadequate dosing.
While Symbicort is generally highly effective for long-term respiratory control, it can cause side effects that vary from person to person. Understanding these effects helps patients use the medication safely and recognize when medical follow-up may be needed.
Most side effects associated with Symbicort are mild and temporary, especially when proper inhaler technique is followed.
These side effects are typically manageable and do not require discontinuing therapy. However, if symptoms persist or interfere with daily activities, patients should speak with their healthcare provider about adjusting their treatment plan or evaluating inhaler technique.
While uncommon, some more serious side effects can occur with Symbicort, particularly if it is used incorrectly or in higher-than-recommended doses.
Prompt medical attention is recommended if symptoms are severe or do not improve.
Significant weight gain is not commonly associated with Symbicort. Because budesonide is inhaled, systemic absorption is low compared with oral steroids, greatly reducing metabolic side effects.
In rare cases—particularly with high doses or long-term use—patients may experience mild weight changes, fluid retention, or subtle metabolic effects, especially if using other corticosteroids. The formoterol component may cause temporary increases in heart rate or blood pressure, which are usually mild.
Routine monitoring, a healthy lifestyle, and regular follow-up help ensure ongoing safety, and any concerning changes can be addressed through dose adjustment or supportive strategies.
Certain medications can interact with Symbicort, altering its effects or increasing the risk of side effects. Because of this, patients need to inform their healthcare provider of all medications, supplements, and over-the-counter products they use.
By maintaining open communication with healthcare providers and regularly reviewing all medications, patients can safely integrate Symbicort into their treatment plan to achieve effective, stable asthma or COPD control.
Administration & Dosage
Symbicort is administered using an aerosol inhaler that delivers a metered dose of medication. Before each use, shake the inhaler well, then remove the mouthpiece cover. Exhale fully to prepare your lungs for the dose. Place the mouthpiece between your teeth and seal your lips around it. Press down on the canister while inhaling slowly and deeply through your mouth. Hold your breath for about 10 seconds to allow the medication to settle in your lungs. Exhale gently. Follow the same steps for the second inhalation if prescribed twice daily as directed by your doctor.
Symbicort is not a dry powder inhaler. It is an aerosol inhaler that delivers medication as a mist. The aerosol form ensures a specific dose of medication is inhaled with each use, unlike dry powder inhalers.
Typically, Symbicort is taken as 2 inhalations twice a day, once in the morning and once in the evening, with a 12-hour interval between doses. However, your healthcare provider might adjust the dosage depending on your health condition and response to the treatment.
Symbicort is not intended for use as a rescue inhaler. It should not be used to relieve sudden asthma symptoms or acute COPD flare-ups. Quick-relief or rescue inhalers, rather than Symbicort, should be used for acute attacks to provide fast-acting relief.
Symbicort is designed for long-term asthma and COPD management, helping maintain ongoing symptom control. The duration of its use will depend on your condition and your response to treatment. Your doctor will regularly evaluate your condition and decide how long Symbicort should be continued as part of your treatment plan.
Store Symbicort at room temperature in a dry place, away from direct light and moisture. Do not expose the inhaler to freezing temperatures. Always ensure the inhaler cap is securely replaced after use to maintain device hygiene and effectiveness. Avoid storing it in high temperatures, such as in a car on a hot day.
Uses & Mechanism of Action
Symbicort is primarily used to manage asthma in patients 6 years and older and chronic obstructive pulmonary disease (COPD) in adults. It helps control asthma symptoms and prevent flare-ups, reducing hospital visits due to severe asthma attacks. It’s also effective in managing COPD by decreasing exacerbations and improving airflow in the lungs.
Symbicort is a combination medication that reduces inflammation in the airways and improves breathing. It helps widen air passages by targeting two primary symptoms of respiratory conditions: inflammation and airway constriction. Its dual-action not only relieves symptoms but also helps prevent them from worsening.
Symbicort combines two key medications: budesonide and formoterol. Budesonide is a corticosteroid that reduces inflammation and swelling in the airways. At the same time, formoterol is a long-acting beta-agonist (LABA) that helps relax and open up the muscles around the airways, making breathing easier. This combination provides both immediate symptom relief and long-term control of inflammation.
Symbicort contains budesonide, which is a corticosteroid. This component of the medication plays a crucial role in reducing inflammation, helping to control symptoms and prevent the progression of respiratory diseases.
Many patients experience some improvement in their symptoms shortly after using Symbicort, often within 15 minutes, due to the rapid action of formoterol. However, the full therapeutic effects, particularly from the anti-inflammatory benefits of budesonide, may take a week or two to become noticeable.
Side Effects & Safety
Some common side effects of Symbicort include throat irritation, headache, nausea, and sinusitis. Users may also experience coughing, back pain, or changes in voice, such as hoarseness. It is crucial to report any severe or persistent side effects to your healthcare provider to ensure your treatment is safe and effective.
Weight gain is not a typical side effect of Symbicort, though it has been associated with corticosteroids in general. Long-term use of corticosteroids such as budesonide can lead to weight gain in some individuals due to changes in metabolic rate or increased appetite.
While not commonly associated with high blood pressure, patients with a history of hypertension should consult with their healthcare provider about their specific risks. If you experience any unusual symptoms while using Symbicort, it's important to seek medical advice.
While back pain is a less common side effect of Symbicort, it can occur in some individuals. This might be related to the drug's muscle-relaxant properties, which affect musculoskeletal tissues. If you experience significant or persistent back pain, discussing this with your healthcare provider can help determine if Symbicort is the cause.
Thrush, a fungal infection of the mouth or throat, can occur with the use of inhaled corticosteroids such as budesonide. To reduce the risk of thrush, patients should rinse their mouth with water and spit it out after using the inhaler. Using a spacer device with the inhaler can also help minimize exposure to the oral cavity.
Interactions & Contraindications
Albuterol, a short-acting bronchodilator, can be used alongside Symbicort as a rescue inhaler for quick relief of sudden breathing issues. Always follow your healthcare provider's advice on the simultaneous use of these medications to ensure safety and effectiveness.
Antihistamines are generally safe to use with Symbicort. However, it's essential to confirm with your healthcare provider, especially if you are managing other conditions or taking additional medications, to avoid possible interactions that could affect treatment outcomes.
In certain cases, Symbicort and Spiriva may be prescribed together for severe COPD management. They work in complementary ways, using different mechanisms to improve lung function and manage symptoms. Consulting with a healthcare provider is vital to identifying if this combination is appropriate for your specific needs.
Patients using Symbicort should avoid exposure to respiratory triggers such as smoke or allergens that may worsen asthma or COPD symptoms. Following any lifestyle or dietary advice from your healthcare provider will also help improve the management of your condition.
There are no specific dietary restrictions when using Symbicort, so you can eat after using your inhaler. Maintaining a well-balanced diet will help manage your overall health while using Symbicort as part of your treatment regimen.
Generic & Alternatives
A generic version of Symbicort that contains the same active ingredients, budesonide and formoterol, is available. This can be a more cost-effective option while providing the same therapeutic benefits as the branded version.
Generic options such as the budesonide/formoterol combination can be less expensive than the branded Symbicort. Other alternatives, depending on your specific condition, might include medications like Advair. Always consult your healthcare provider to determine the best, most cost-effective option for your situation.
Breyna is a generic equivalent of Symbicort, containing the same active ingredients and offering similar benefits for the treatment of asthma and COPD. It has been approved for use at the same level of effectiveness as the brand-name medication.
Symbicort and Advair are both inhalers used to treat asthma and COPD, but contain different active ingredient combinations. Advair includes fluticasone and salmeterol, while Symbicort contains budesonide and formoterol. Your healthcare provider can guide you in choosing the most suitable option based on your medical condition and response to treatment.
The cost of Symbicort without insurance can vary widely, often ranging from a couple of hundred to several hundred dollars. Prices may be lower if opting for the generic version or when using pharmacy discount programs.
Symbicort functions as a bronchodilator in part because it includes formoterol, which helps to relax and open the airways in the lungs. This bronchodilation makes breathing easier by increasing airflow and reducing resistance in the respiratory airways.
By helping to reduce inflammation and open airways, Symbicort may facilitate the loosening and coughing up of phlegm. This action can help improve breathing and reduce chest congestion over time, particularly in patients with COPD.
Symbicort coverage is often available under Medicare Part D or Medicare Advantage plans that include prescription drug coverage. However, individual plan details can vary, so it's advisable to consult your specific Medicare plan provider to confirm coverage details.