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Fluticasone propionate is the generic version of Flovent HFA and Flovent Diskus, an inhaled corticosteroid used every day to prevent asthma symptoms in adults and children 4 years and older. It calms inflammation in the airways so they are less sensitive, less swollen, and less likely to tighten up. We carry the Prasco authorized generic in both the HFA metered-dose inhaler (44, 110, and 220 mcg) and the Diskus dry powder inhaler (50, 100, and 250 mcg). It is a maintenance medicine, not a rescue inhaler, and is available by prescription only.
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Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Fluticasone propionate is the generic version of Flovent HFA and Flovent Diskus, an inhaled corticosteroid used every day to prevent asthma symptoms in adults and children 4 years and older. It calms inflammation in the airways so they are less sensitive, less swollen, and less likely to tighten up. We carry the Prasco authorized generic in both the HFA metered-dose inhaler (44, 110, and 220 mcg) and the Diskus dry powder inhaler (50, 100, and 250 mcg). It is a maintenance medicine, not a rescue inhaler, and is available by prescription only.
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Important safety information
Fluticasone propionate inhalers should not be used in the following situations:
Status asthmaticus or acute asthma attacks that need intensive emergency treatment
Known hypersensitivity to fluticasone propionate or any ingredient in the inhaler
Diskus only: severe allergy to milk proteins, because the powder contains lactose
Active or untreated tuberculosis, or untreated fungal, bacterial, viral, or parasitic infections
Herpes infection of the eye
Recent switch from oral steroids
Osteoporosis or risk factors for low bone density
Glaucoma, cataracts, or increased eye pressure
Liver disease
Pregnancy or breastfeeding; discuss risks and benefits with your prescriber
Albuterol is a prescription bronchodilator that helps open the airways in the lungs. Albuterol is used to prevent and treat bronchospasm in people with asthma, chronic obstructive pulmonary disease (COPD), and other breathing disorders. It works quickly by relaxing the muscles around the airways, often providing relief within minutes during asthma attacks or episodes of sudden shortness of breath. It is available by prescription only in several forms, including metered-dose inhalers (such as ProAir HFA), nebulizer solutions (such as AccuNeb), and tablets.
Budesonide is a prescription corticosteroid used as a daily maintenance treatment to prevent and control asthma symptoms in adults and children. By reducing airway inflammation and swelling, it improves breathing and helps prevent asthma attacks. It is available as a dry powder inhaler and as a nebulizer suspension for those who have difficulty using inhalers. Budesonide must be used consistently as prescribed, even when symptoms are absent. After each use, rinse your mouth with water to help prevent oral thrush, a common side effect.
Symbicort is a prescription combination inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD). It contains a corticosteroid to reduce airway inflammation and a long-acting bronchodilator to relax airway muscles, improving breathing. Used daily as maintenance therapy, Symbicort helps prevent asthma attacks and COPD flare-ups but is not intended for sudden breathing issues. It must be used exactly as prescribed and not for acute shortness of breath—use a rescue inhaler instead. Rinse your mouth with water after each use to help prevent oral thrush.
Fluticasone propionate is a corticosteroid nasal spray used to treat nasal congestion, sneezing, and a runny or itchy nose caused by seasonal, perennial, or nonallergic rhinitis. It works by reducing inflammation in the nasal passages to relieve allergy symptoms at their source. While not a decongestant, consistent daily use typically controls symptoms within several days.
Fluticasone propionate and Salmeterol is a prescription inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines a corticosteroid to reduce airway inflammation and a long-acting beta₂-agonist (LABA) to relax airway muscles, helping to prevent wheezing, coughing, and shortness of breath. It is taken regularly, usually twice daily, for long-term symptom control and is not a rescue inhaler.
Hydroxyzine hydrochloride is a prescription antihistamine used to treat a range of conditions, including anxiety, allergic reactions, itching (pruritus), and nausea, as well as for sedation before or after medical procedures. By acting on the central nervous system, hydroxyzine produces calming and sedative effects while also blocking histamine-related symptoms such as itching and hives. It is often prescribed for short-term or intermittent use, particularly when non-sedating treatments are ineffective or inappropriate.
Fluticasone propionate is an inhaled corticosteroid (ICS) used as daily maintenance therapy to prevent asthma symptoms in adults and children 4 years and older. Inhaled steroids are the backbone of long-term asthma control: they reduce the airway inflammation that drives wheezing, coughing, chest tightness, and flare-ups.
Because the medicine is breathed directly into the lungs, it works where it is needed at doses far lower than steroid tablets. Less medicine reaches the rest of the body, which lowers the risk of the side effects linked to oral steroids.
Drug class: Inhaled corticosteroid
Brand names: Flovent HFA, Flovent Diskus
Forms we carry: HFA inhaler (44, 110, 220 mcg per puff) and Diskus powder inhaler (50, 100, 250 mcg per blister)
Manufacturer: Prasco Laboratories (authorized generic)
Prescription: Required
Flovent is the original brand of fluticasone propionate, developed by GSK. Flovent HFA is a pressurized metered-dose inhaler, and Flovent Diskus is a breath-activated dry powder inhaler. GSK stopped selling branded Flovent HFA and Flovent Diskus in the US in January 2024 and replaced them with authorized generics.
The fluticasone propionate inhalers we dispense are those authorized generics from Prasco. An authorized generic is made from the same formula and the same device as the brand, just sold without the brand name. Patients switching from Flovent get the same medicine, the same dose counter, and the same technique.
Fluticasone propionate HFA and Diskus are FDA approved for the maintenance treatment of asthma as preventive (prophylactic) therapy in patients 4 years of age and older.
Reduces daily asthma symptoms such as wheezing, cough, and shortness of breath
Lowers the risk of asthma attacks and flare-ups
Reduces nighttime awakenings and reliance on a rescue inhaler
Can help some patients reduce or stop oral steroid use under a prescriber's supervision
Fluticasone propionate is not a rescue inhaler and does not relieve sudden breathing problems. Patients should always keep a fast-acting bronchodilator such as albuterol on hand for acute symptoms. Flovent HFA and Diskus are not approved for COPD; fluticasone combined with salmeterol (Advair, Wixela) is the product used for COPD.
Fluticasone propionate is a synthetic corticosteroid with strong anti-inflammatory activity. It binds to glucocorticoid receptors inside airway cells with high affinity and switches off many of the signals that keep asthma inflammation going.
Reduces the number and activity of inflammatory cells in the airways, including eosinophils, mast cells, and lymphocytes
Lowers production of inflammatory messengers such as cytokines, histamine, and leukotrienes
Decreases airway swelling and mucus, and makes the airways less reactive to triggers
Some patients notice improvement within 24 hours, but full benefit usually takes 1 to 2 weeks or longer of consistent daily use. Most of any swallowed drug is broken down by the liver (CYP3A4) on its first pass, so very little reaches the bloodstream, which is why systemic side effects are uncommon at usual doses.
Fluticasone propionate is taken by inhalation twice daily, about 12 hours apart, every day, even when breathing feels normal. Your prescriber chooses the strength based on asthma severity and prior therapy.
HFA inhaler: 44 mcg, 110 mcg, and 220 mcg per actuation, 120 puffs per inhaler
Diskus inhaler: 50 mcg, 100 mcg, and 250 mcg per blister, 60 blisters per device
HFA, adults and children 12+: 88 mcg to 880 mcg twice daily (maximum 880 mcg twice daily)
HFA, children 4 to 11: 88 mcg twice daily
Diskus, adults and children 12+: 100 mcg to 1,000 mcg twice daily (maximum 1,000 mcg twice daily)
Diskus, children 4 to 11: 50 mcg twice daily, up to 100 mcg twice daily
At 2 puffs or 1 blister twice a day, one HFA inhaler or one Diskus covers 30 days.
Prime before first use by spraying 4 times into the air away from your face, shaking for 5 seconds before each spray. Re-prime with 1 spray if unused for more than 7 days or if dropped.
Shake for 5 seconds, breathe out fully, then inhale slowly and deeply while pressing down on the canister. Hold your breath for about 10 seconds.
Wait about 30 seconds and shake again before a second puff. A spacer can help with technique.
Open the device and slide the lever until it clicks to load a dose. Do not shake it.
Breathe out away from the mouthpiece, then breathe in quickly and deeply through it. Hold your breath for about 10 seconds.
Never breathe into the device or wash it, and keep it dry.
After every dose of either device, rinse your mouth with water and spit it out without swallowing to lower the risk of thrush and hoarseness.
Most people tolerate inhaled fluticasone well. Side effects are usually mild and local to the mouth and throat.
Upper respiratory infection, sinus irritation, or stuffy nose
Sore or irritated throat
Hoarseness or voice changes
Oral thrush (yeast infection of the mouth or throat)
Headache and cough
Worsening asthma or acute attacks: not a rescue medicine; seek care if symptoms worsen or rescue inhaler use increases
Paradoxical bronchospasm: sudden wheezing right after a dose; use a rescue inhaler and call your prescriber
Infections: higher risk or more severe chickenpox and measles in people not immune; report exposure
Adrenal insufficiency: possible when switching from oral steroids or at high doses
Bone and eye effects: reduced bone density, glaucoma, and cataracts with long-term use
Slowed growth in children: growth should be monitored; use the lowest effective dose
Allergic reactions: rash, hives, or swelling of the face, mouth, or tongue
Fluticasone is broken down by the liver enzyme CYP3A4. Medicines that strongly block this enzyme can raise fluticasone levels in the body and cause steroid side effects such as Cushing's syndrome and adrenal suppression.
Ritonavir and cobicistat-boosted HIV medicines (for example, Paxlovid, Kaletra, Prezcobix, Genvoya)
Strong azole antifungals such as ketoconazole, itraconazole, and voriconazole
Clarithromycin and other strong CYP3A4 inhibitors such as nefazodone
Other corticosteroids (tablets, injections, nasal sprays, creams), which add to total steroid exposure
Moderate CYP3A4 inhibitors such as erythromycin
Tell your prescriber and pharmacist about every prescription, over-the-counter medicine, and supplement you take. Our pharmacists screen every order for interactions.
Asthma Treatment
Fluticasone propionate is used every day to prevent asthma symptoms and attacks in adults and children 4 years and older. It reduces airway inflammation so your lungs are less reactive to triggers like allergens, cold air, and exercise.
No. Fluticasone is a controller medicine and will not open your airways quickly during an attack. Always carry a fast-acting rescue inhaler such as albuterol for sudden symptoms.
Some people feel better within 24 hours, but it usually takes 1 to 2 weeks of twice-daily use to reach full effect. Keep taking it every day even when you feel well.
Flovent HFA and Flovent Diskus are approved for asthma, not COPD. For COPD, prescribers typically use combination inhalers such as fluticasone/salmeterol (Advair, Wixela), which we also carry.
Administration & Dosage
Most patients use it twice a day, about 12 hours apart. The HFA inhaler is typically 2 puffs per dose and the Diskus is 1 blister per dose, but always follow your prescription label.
Each HFA inhaler has 120 puffs and each Diskus has 60 blisters. At the most common dose of 2 puffs or 1 blister twice daily, one device lasts 30 days. Order 3 for a 90-day supply.
Before first use, shake for 5 seconds and spray 4 times into the air away from your face. If you have not used it in more than 7 days or you dropped it, shake and spray once to re-prime.
Rinsing with water and spitting it out removes leftover medicine from your mouth and throat. This simple step lowers your risk of oral thrush and hoarseness.
Skip the missed dose and take your next dose at the regular time. Do not take two doses at once to make up for one you missed.
The HFA is a pressurized spray inhaler you press and breathe in slowly, and it works with a spacer. The Diskus is a breath-activated powder that needs a quick, deep breath and no coordination with a button. Your prescriber picks the device that fits your technique and age.
Uses & Mechanism of Action
Fluticasone is a corticosteroid that turns down inflammation inside the airways. It reduces inflammatory cells and chemicals, lowers swelling and mucus, and makes airways less sensitive over time.
Yes, it is a corticosteroid, but it is not an anabolic steroid. Because it is inhaled, only a small amount reaches the bloodstream compared with steroid tablets like prednisone.
Side Effects & Safety
The most common side effects are upper respiratory infection, throat irritation, hoarseness, headache, cough, and oral thrush. Rinsing your mouth after each dose helps prevent the mouth and throat effects.
Inhaled corticosteroids may slightly slow growth rate in some children. Prescribers use the lowest dose that controls asthma and monitor growth at regular visits. Uncontrolled asthma also carries real risks for kids.
Talk with your prescriber. Well-controlled asthma is important for both parent and baby, and your prescriber will weigh the benefits of inhaled steroids against any risks.
Call your prescriber if you need your rescue inhaler more often, wake up at night with asthma, notice white patches in your mouth, or get wheezing right after a dose. Seek emergency care for severe shortness of breath or signs of an allergic reaction.
Interactions & Contraindications
Strong CYP3A4 inhibitors such as ritonavir, cobicistat, ketoconazole, itraconazole, and clarithromycin can raise fluticasone levels and are not recommended. Share your full medication list with your prescriber and our pharmacists.
Do not use it to treat an acute asthma attack or status asthmaticus, or if you are allergic to fluticasone. People with a severe milk protein allergy should not use the Diskus because it contains lactose.
Generic & Alternatives
Yes. We dispense the Prasco authorized generic, which is made with the same formula and device as Flovent HFA and Flovent Diskus. Only the label and price are different.
GSK discontinued branded Flovent HFA and Flovent Diskus in the US in January 2024. The authorized generic fluticasone propionate took its place, so most patients switching from Flovent can continue the same dose.
Other inhaled corticosteroids include budesonide, mometasone, beclomethasone, and fluticasone furoate. Combination inhalers such as fluticasone/salmeterol and budesonide/formoterol add a long-acting bronchodilator. Your prescriber can help choose the best fit.
Ordering & Pricing
Yes, a valid prescription is required. Your prescriber can send it to us directly, you can transfer an existing prescription, or eligible patients can request a refill through our telemedicine partners.
Yes. Invictus Pharmacy is licensed in all 50 states and has served more than 2.1 million patients. We ship fluticasone propionate to your door with transparent cash prices and no insurance required.
Yes. Ordering 2 or 3 inhalers at once lowers your cost per inhaler and means fewer refills to manage, so you are less likely to run out of your controller medicine.