Hydroxyzine hydrochloride is a prescription antihistamine used to treat a range of conditions, including anxiety, allergic reactions, itching (pruritus), and nausea, as well as for sedation before or after medical procedures. By acting on the central nervous system, hydroxyzine produces calming and sedative effects while also blocking histamine-related symptoms such as itching and hives. It is often prescribed for short-term or intermittent use, particularly when non-sedating treatments are ineffective or inappropriate.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
Form
Strength
How would you like to get this medication?
Choose a strength and quantity to continue.
Hydroxyzine hydrochloride is a prescription antihistamine used to treat a range of conditions, including anxiety, allergic reactions, itching (pruritus), and nausea, as well as for sedation before or after medical procedures. By acting on the central nervous system, hydroxyzine produces calming and sedative effects while also blocking histamine-related symptoms such as itching and hives. It is often prescribed for short-term or intermittent use, particularly when non-sedating treatments are ineffective or inappropriate.
Complete a health screening
A short questionnaire about your health history and current symptoms — takes about 2 minutes.
Provider reviews your answers
Provider review within 24 hours.
Prescription fulfilled
If approved, your Rx is sent to Invictus Pharmacy and you're notified by text or email. Free nationwide shipping.
Important safety information
Hydroxyzine is not appropriate for everyone, and certain circumstances require special caution or complete avoidance of the drug.
Hydroxyzine is also sometimes used in veterinary medicine. Veterinarians may prescribe it for dogs with allergies, itching, or anxiety. However, animal dosages differ from human doses, and hydroxyzine should never be administered to pets without professional guidance.
Albuterol is a prescription bronchodilator that helps open the airways in the lungs. Albuterol is used to prevent and treat bronchospasm in people with asthma, chronic obstructive pulmonary disease (COPD), and other breathing disorders. It works quickly by relaxing the muscles around the airways, often providing relief within minutes during asthma attacks or episodes of sudden shortness of breath. It is available by prescription only in several forms, including metered-dose inhalers (such as ProAir HFA), nebulizer solutions (such as AccuNeb), and tablets.
Budesonide is a prescription corticosteroid used as a daily maintenance treatment to prevent and control asthma symptoms in adults and children. By reducing airway inflammation and swelling, it improves breathing and helps prevent asthma attacks. It is available as a dry powder inhaler and as a nebulizer suspension for those who have difficulty using inhalers. Budesonide must be used consistently as prescribed, even when symptoms are absent. After each use, rinse your mouth with water to help prevent oral thrush, a common side effect.
Symbicort is a prescription combination inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD). It contains a corticosteroid to reduce airway inflammation and a long-acting bronchodilator to relax airway muscles, improving breathing. Used daily as maintenance therapy, Symbicort helps prevent asthma attacks and COPD flare-ups but is not intended for sudden breathing issues. It must be used exactly as prescribed and not for acute shortness of breath—use a rescue inhaler instead. Rinse your mouth with water after each use to help prevent oral thrush.
Fluticasone propionate is a corticosteroid nasal spray used to treat nasal congestion, sneezing, and a runny or itchy nose caused by seasonal, perennial, or nonallergic rhinitis. It works by reducing inflammation in the nasal passages to relieve allergy symptoms at their source. While not a decongestant, consistent daily use typically controls symptoms within several days.
Fluticasone propionate is the generic version of Flovent HFA and Flovent Diskus, an inhaled corticosteroid used every day to prevent asthma symptoms in adults and children 4 years and older. It calms inflammation in the airways so they are less sensitive, less swollen, and less likely to tighten up. We carry the Prasco authorized generic in both the HFA metered-dose inhaler (44, 110, and 220 mcg) and the Diskus dry powder inhaler (50, 100, and 250 mcg). It is a maintenance medicine, not a rescue inhaler, and is available by prescription only.
Fluticasone propionate and Salmeterol is a prescription inhaler used to manage asthma and chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines a corticosteroid to reduce airway inflammation and a long-acting beta₂-agonist (LABA) to relax airway muscles, helping to prevent wheezing, coughing, and shortness of breath. It is taken regularly, usually twice daily, for long-term symptom control and is not a rescue inhaler.
Hydroxyzine hydrochloride is a prescription sedating antihistamine used to treat conditions such as anxiety, itching due to allergic reactions, nausea, and tension, as well as for short-term sedation in certain clinical settings.
It works by blocking histamine receptors and depressing activity in the central nervous system, producing calming and anti-itch effects. Unlike benzodiazepines, hydroxyzine hydrochloride does not act on GABA receptors and is not habit-forming, making it a non-controlled option for short-term anxiety relief.
Because it can cause drowsiness, dizziness, and slowed reaction time, patients should avoid driving or operating machinery until they know how the medication affects them. Alcohol and other sedatives may intensify these effects and should be avoided unless approved by a healthcare provider.
Note: This medication’s generic and brand-name formulations are used interchangeably throughout this article.
Atarax and Orgatrax are brand names for hydroxyzine hydrochloride. Atarax was once widely prescribed in the United States for anxiety, allergic reactions, and itching, but it was discontinued in the U.S. in 2021. Despite this, hydroxyzine hydrochloride remains readily available in generic form and is still commonly prescribed.
Orgatrax is another brand-name version containing the same active ingredient.
If you encounter references to Atarax in older prescriptions, clinical studies, or online resources, it simply refers to hydroxyzine hydrochloride. Today, most healthcare providers prescribe the medication under its generic name, which is equally safe and effective.
It’s important to distinguish hydroxyzine hydrochloride from hydroxyzine pamoate (Vistaril), which is a different salt form of hydroxyzine. Although both contain the same active drug, they differ in formulation and absorption characteristics and may be selected based on specific treatment goals.
This page focuses specifically on hydroxyzine hydrochloride, the form historically marketed as Atarax and Orgatrax.
Hydroxyzine hydrochloride is a prescription sedating antihistamine that has been used for decades to manage a range of conditions involving both histamine-related reactions and central nervous system symptoms.
Its ability to block histamine activity while producing calming effects makes it useful in several areas of short-term care, particularly when non-addictive treatment options are preferred.
Common uses include:
Hydroxyzine hydrochloride is commonly prescribed for short-term anxiety relief. By calming activity in the central nervous system, it may help reduce symptoms such as nervousness, restlessness, and tension. Unlike benzodiazepines, hydroxyzine hydrochloride is non-habit-forming and non-controlled, making it an option for patients who require temporary anxiety support or who cannot take medications with dependence potential.
As an antihistamine, hydroxyzine hydrochloride is effective in treating itching, hives, and other allergic skin reactions. Blocking histamine receptors helps reduce swelling, redness, and discomfort associated with allergic responses. It is often prescribed for chronic urticaria or persistent itching that has not responded adequately to over-the-counter antihistamines.
Hydroxyzine hydrochloride may be used to control nausea and vomiting, particularly when associated with motion sickness, post-surgical recovery, or certain medical treatments. Its anti-nausea effects are thought to result from both its sedative properties and its ability to dampen brain signals that trigger vomiting.
Because it commonly causes drowsiness, hydroxyzine hydrochloride is sometimes prescribed as a short-term sleep aid, especially for individuals whose insomnia is related to anxiety or allergic symptoms. While it does not carry the same dependence risks as traditional sleep medications, it should still be used under medical supervision to avoid excessive sedation or next-day impairment.
In some cases, hydroxyzine hydrochloride may be used before or after surgical procedures to help promote relaxation or reduce nausea. It may also be prescribed in pediatric patients for allergies or anxiety, with careful dose adjustments based on age and weight to ensure safety.
Hydroxyzine hydrochloride primarily blocks histamine H1 receptors, helping reduce allergic symptoms such as itching, hives, swelling, and skin irritation. By preventing histamine from binding to these receptors, it limits the immune response responsible for many allergy-related reactions.
In addition to its antihistamine effects, hydroxyzine hydrochloride also acts on the central nervous system (CNS). It can cross the blood–brain barrier, where it produces sedative and calming effects by suppressing certain brain regions. This CNS action explains its usefulness in managing anxiety, tension, nausea, and sleep disturbances.
Hydroxyzine does not work immediately but is considered a fast-acting antihistamine, with slight to substantial sedative effects depending on dosage. The timeline of action depends on the dose, the individual’s metabolism, and whether the medication is taken with food.
Most people notice effects within 30 minutes of taking hydroxyzine, with peak effectiveness in about 2 hours. Because of this relatively quick onset, it’s often prescribed for acute anxiety episodes, sudden itching, or short-term sleep support.
The clinical effects typically last 4–6 hours, which means patients may need multiple doses throughout the day if it’s being used for itching or anxiety. For sleep, a single bedtime dose is often sufficient to maintain sleep throughout the night.
Even after its noticeable effects wear off, hydroxyzine remains in the body for a longer period. Its half-life is approximately 20 hours in adults, meaning it can remain in the system for a day or more. In older adults or those with liver or kidney problems, the drug may linger longer, which is why doctors may recommend lower doses.
Because of its extended half-life, hydroxyzine can accumulate in your body with repeated use, leading to more substantial sedative effects if taken too frequently. Always follow your healthcare provider’s dosing instructions to avoid excessive drowsiness or other side effects.
Hydroxyzine hydrochloride is prescribed in different strengths depending on the condition being treated, patient age, and overall health status. It is available as tablets, capsules, liquid formulations, and, in some clinical settings, injectable formulations.
As with many sedating medications, the goal is to use the lowest effective dose for the shortest duration necessary, thereby minimizing side effects such as drowsiness, dizziness, and impaired coordination.
For adults, typical daily doses of hydroxyzine hydrochloride range from 25 to 100 mg, administered in 2 to 4 divided doses per day, depending on the indication. For conditions such as itching or anxiety, a common prescription may be 25 mg taken up to four times daily. In some cases, providers may adjust the dose upward if symptoms persist and the medication is well tolerated.
Higher daily doses—such as 200 mg—are considered above routine use and may increase the risk of side effects, including excessive sedation, confusion, dry mouth, or changes in heart rhythm. While such doses may occasionally be prescribed for specific clinical situations, such as preoperative sedation, they should only be taken under close medical supervision.
The maximum recommended adult daily dose is typically up to 400 mg, reserved for severe cases and generally managed in controlled or monitored settings. Most patients receive significantly lower doses during routine treatment.
For children, hydroxyzine hydrochloride dosing is weight-based and carefully calculated to reduce the risk of excessive sedation or adverse effects. Pediatric use should always follow precise prescribing instructions and be accompanied by ongoing monitoring by a healthcare provider.
Like all medications, hydroxyzine can cause side effects, though most are mild and temporary. Many patients tolerate it well, especially when it’s prescribed at the lowest effective dose. Still, being aware of potential side effects helps you use hydroxyzine safely and recognize when you should contact a healthcare provider.
The most frequently reported side effects include:
Other possible, less-reported side effects include:
Although uncommon, serious side effects can occur and require immediate medical attention. These may include:
If you experience any of these symptoms, stop taking hydroxyzine and seek medical attention immediately.
When used as prescribed, hydroxyzine is generally well tolerated. However, like all medications, it carries some risks. Taking more than the recommended amount can lead to serious side effects such as severe drowsiness, confusion, seizures, or irregular heart rhythms.
As with any prescription medication, hydroxyzine should only be taken under the supervision of a healthcare provider. Patients should avoid self-adjusting their dose, combining it with alcohol, or using it with other sedating drugs without medical guidance. Seek emergency care if you experience a racing heartbeat, severe dizziness, or fainting while taking this medication.
Hydroxyzine hydrochloride can interact with medications that affect the central nervous system or heart rhythm, increasing the risk of side effects. Because it has sedating properties, combining it with other drugs that cause drowsiness should be done only under medical supervision.
Medications such as benzodiazepines, opioid pain relievers, sleep aids, muscle relaxants, and alcohol may intensify sedation, dizziness, and impaired coordination when taken with hydroxyzine hydrochloride. These combinations can reduce alertness and increase the risk of falls or accidents, particularly in older adults.
Hydroxyzine hydrochloride may also interact with other antihistamines, including over-the-counter allergy or cold medications. Using multiple antihistamines together can increase anticholinergic effects such as dry mouth, blurred vision, constipation, urinary retention, and confusion.
Caution is advised when hydroxyzine hydrochloride is used alongside medications that affect heart rhythm, including certain antibiotics, antifungals, and psychiatric medications, as these combinations may increase the risk of QT interval prolongation. Patients should inform their healthcare provider of all medications and supplements they are taking to ensure safe and coordinated use.
Administration & Dosage
For most adults, typical doses range from 25 mg to 100 mg per day, divided into two to four smaller doses. Some people may take 25 mg up to four times daily for itching or anxiety. In rare situations, such as before surgery, doctors may prescribe higher doses under close supervision. The maximum recommended daily amount for adults is around 400 mg, though most patients take far less regularly.
Hydroxyzine is usually taken every 6 to 8 hours, depending on how your body responds and on your doctor's instructions. Dividing the daily dose into smaller, evenly spaced amounts helps maintain consistent symptom relief while reducing the risk of excessive drowsiness or dizziness. You should never take more frequent doses than recommended, and always follow your doctor’s exact schedule for safe use.
Hydroxyzine is available in several forms, including tablets, capsules, syrup, and, in some cases, injectable solutions administered in medical settings. This variety allows healthcare providers to tailor treatment to each patient’s needs and preferences. Regardless of the form, it’s important to take hydroxyzine exactly as prescribed and use the lowest effective dose for the shortest time necessary to minimize potential side effects.
It’s best to avoid alcohol entirely while taking hydroxyzine. Alcohol enhances the drug’s sedative and depressant effects, increasing the risk of drowsiness, poor coordination, and, in some cases, respiratory depression. Waiting 12 hours may reduce the risk slightly, but consult your healthcare provider before drinking while on hydroxyzine.
Uses & Mechanism of Action
Hydroxyzine hydrochloride (Atarax) is an antihistamine that helps manage anxiety, itching, nausea, and allergic reactions. It works by blocking histamine, a natural chemical responsible for allergy symptoms, while also calming the brain through its sedative properties. This dual effect makes it useful for both allergic and anxiety-related conditions.
Hydroxyzine pamoate (Vistaril) is a specific form of hydroxyzine prescribed to relieve anxiety, tension, and skin conditions caused by allergies. It can also be used before surgery to help patients relax. Like other antihistamines, it works by reducing histamine activity while also calming the central nervous system.
Hydroxyzine belongs to the antihistamine class of medications, not the benzodiazepine family. While both can reduce anxiety and promote better sleep, hydroxyzine works by blocking histamine receptors rather than affecting GABA activity in the brain. This means it provides calming benefits without the dependency risks or withdrawal symptoms associated with benzodiazepines.
Side Effects & Safety
No. Hydroxyzine is not classified as a controlled substance in the United States, meaning it has no significant potential for abuse or dependence. However, it is only available by prescription, as improper use can still cause unwanted side effects such as excessive drowsiness or impaired coordination.
Hydroxyzine is not habit-forming and does not produce withdrawal symptoms when discontinued. Because of its non-addictive profile, healthcare providers often choose it as a safer alternative to benzodiazepines for managing anxiety or insomnia. Even so, it should only be taken as directed to avoid excessive sedation or other side effects.
Yes. Taking more than the recommended dose can cause serious complications such as extreme drowsiness, confusion, seizures, or irregular heart rhythms. In severe cases, overdose can lead to cardiac arrest. If an overdose is suspected, seek emergency medical care immediately.
No. Hydroxyzine does not produce euphoria or stimulant effects. At high doses, it primarily causes sedation, making it unsuitable and unsafe for recreational use. Its calming effects come from histamine receptor blockade, not from the reward pathways associated with addictive substances.
Hydroxyzine is not typically included in standard drug screening panels. It does not test positive for common controlled substances such as opioids, benzodiazepines, or amphetamines. However, patients undergoing specialized testing should disclose all medications to their healthcare provider or testing facility to avoid confusion.
Interactions & Contraindications
It is not recommended. Both hydroxyzine and Benadryl (diphenhydramine) are sedating antihistamines. Taking them together can intensify drowsiness, impair coordination, and increase the risk of side effects such as dry mouth, constipation, or confusion—especially in older adults. Only combine them if specifically directed by a healthcare provider.
This combination can significantly increase sedation and dizziness. Both hydroxyzine and Xanax suppress central nervous system activity, which can slow reflexes and impair breathing at high doses. Only take them together if prescribed by your doctor, and never mix them with alcohol or other sedatives.
Generic & Alternatives
Both are antihistamines, but they are not the same. Benadryl (diphenhydramine) is typically used for short-term allergy or sleep relief, while hydroxyzine is often prescribed for anxiety, chronic itching, and nausea. Hydroxyzine tends to have a longer-lasting and more sedating effect, which makes it more suitable for ongoing management of anxiety and skin irritation.
Xanax (alprazolam) is a benzodiazepine that directly targets GABA receptors to relieve anxiety, but can cause dependence with long-term use. Hydroxyzine, on the other hand, is non-addictive and works through antihistamine effects to reduce restlessness, tension, and anxiety. It is sometimes prescribed as an alternative to Xanax for short-term anxiety relief or for patients who should avoid benzodiazepines.
Some people experience mild constipation while taking hydroxyzine, though this side effect is less common than with other sedating medications. Staying hydrated, maintaining a high-fiber diet, and exercising regularly can help minimize this effect.
Hydroxyzine can sometimes lower blood pressure, especially at higher doses or when combined with other sedating or blood-pressure-lowering medications. Patients with low blood pressure or cardiovascular issues should use it cautiously and consult their healthcare provider before starting treatment.
Rarely, hydroxyzine may slow your heart rate, particularly when taken with other central nervous system depressants or medications that affect cardiac rhythm. Anyone experiencing dizziness, fainting, or irregular heartbeat while taking hydroxyzine should contact their doctor immediately.