Atenolol/chlorthalidone is a fixed-dose combination tablet that pairs a beta-1 selective blocker with a thiazide-like diuretic to treat high blood pressure, used when a single agent doesn't provide adequate control.
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Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Atenolol/chlorthalidone combines atenolol, a beta-1 selective (cardioselective) blocker, with chlorthalidone, a thiazide-like diuretic, in a single tablet for hypertension. Atenolol reduces heart rate and cardiac output, while chlorthalidone promotes sodium and water excretion, lowering blood pressure through complementary mechanisms. Common strengths include 50 mg/25 mg and 100 mg/25 mg, typically dosed once daily. Common side effects include fatigue, dizziness, bradycardia, and electrolyte disturbances (particularly hypokalemia and hyponatremia). Beta-blockers should not be stopped abruptly, as this can precipitate rebound hypertension, angina, or arrhythmia; the dose should be tapered gradually. Use caution in patients with asthma/COPD, diabetes (may mask hypoglycemia symptoms), gout, or sulfonamide allergy.
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Atenolol/chlorthalidone is a combination tablet used to treat high blood pressure when a single agent does not provide adequate control. Atenolol, a beta-1 selective blocker, slows heart rate and reduces cardiac output, while chlorthalidone, a thiazide-like diuretic, reduces fluid volume by increasing sodium and water excretion.
Common side effects include fatigue, dizziness, cold hands/feet, bradycardia, and electrolyte changes such as low potassium or sodium.
Important: Do not stop this medication abruptly. Sudden discontinuation of a beta-blocker can cause rebound hypertension, chest pain, or arrhythmia; the dose should be tapered gradually under medical supervision.
Use with caution in patients with asthma or COPD, diabetes (beta-blockers can mask symptoms of low blood sugar), gout, or a sulfa allergy (chlorthalidone is a sulfonamide derivative).