Bisoprolol/hydrochlorothiazide combines a beta-1 selective blocker with a thiazide diuretic in a single tablet to treat high blood pressure, used when a single agent doesn't provide adequate control.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Bisoprolol/hydrochlorothiazide (Ziac) combines bisoprolol, a beta-1 selective blocker, with hydrochlorothiazide, a thiazide diuretic, for the treatment of hypertension. Bisoprolol reduces heart rate and cardiac output, while hydrochlorothiazide reduces fluid volume through increased sodium and water excretion. Available strengths include 2.5 mg/6.25 mg, 5 mg/6.25 mg, and 10 mg/6.25 mg, typically taken once daily. Common side effects include dizziness, fatigue, headache, and electrolyte disturbances such as low potassium. As with other beta-blockers, this medication should not be stopped abruptly; doing so can cause rebound hypertension, chest pain, or arrhythmia, so the dose should be tapered gradually under medical supervision. Use with caution in patients with asthma/COPD, diabetes (may mask signs of low blood sugar), gout, or a sulfa allergy.
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Bisoprolol/hydrochlorothiazide (Ziac) is a combination tablet used to treat high blood pressure when a single agent doesn't provide adequate control. Bisoprolol, a beta-1 selective blocker, slows heart rate and reduces cardiac output, while hydrochlorothiazide, a thiazide diuretic, reduces fluid volume by increasing sodium and water excretion.
Common side effects include dizziness, fatigue, headache, and electrolyte changes such as low potassium.
Important: Do not stop this medication abruptly. Sudden discontinuation of a beta-blocker can cause rebound hypertension, chest pain, or arrhythmia; the dose should be tapered gradually under medical supervision.
Use with caution in patients with asthma or COPD, diabetes (beta-blockers can mask symptoms of low blood sugar), gout, or a sulfa allergy.