Cilostazol (Pletal) is a phosphodiesterase-3 inhibitor used to reduce symptoms of intermittent claudication, improving walking distance in peripheral arterial disease.
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Cilostazol is a phosphodiesterase-3 (PDE3) inhibitor with antiplatelet and vasodilating properties, used to reduce the symptoms of intermittent claudication and improve walking distance in patients with peripheral arterial disease. The typical dose is 100 mg orally twice daily, taken at least 30 minutes before or 2 hours after meals; a reduced dose of 50 mg twice daily is used with certain CYP3A4 or CYP2C19 inhibitors. Common side effects include headache, diarrhea, abnormal stools, dizziness, and palpitations. Cilostazol and other drugs of this class have been shown to reduce survival in patients with class III-IV congestive heart failure, and it is contraindicated in patients with heart failure of any severity.
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Cilostazol (Pletal) is a phosphodiesterase-3 inhibitor with antiplatelet and vasodilating effects, used to reduce symptoms of intermittent claudication and improve walking distance in people with peripheral arterial disease. It should be taken on an empty stomach, at least 30 minutes before or 2 hours after meals.
Boxed Warning: Cilostazol and other drugs in its class have been shown to decrease survival in patients with class III-IV congestive heart failure. Cilostazol is contraindicated in patients with heart failure of any severity.
Common side effects include headache, diarrhea, abnormal stools, dizziness, and palpitations. It should be used cautiously with other antiplatelet or anticoagulant medications due to increased bleeding risk.