Indomethacin

Indomethacin (Indocin) is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin-mediated pain and inflammation. It is used for moderate to severe osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, and bursitis/tendinitis. Indomethacin is generally more potent but less well tolerated than other NSAIDs, with a higher incidence of gastrointestinal and central nervous system side effects (such as headache and dizziness). It carries the same class-wide boxed warnings for cardiovascular and gastrointestinal risk as other NSAIDs and should be taken with food to reduce stomach upset.