Labetalol (Trandate) is a combined alpha- and beta-adrenergic blocker used to treat high blood pressure.
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Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Labetalol (Trandate) blocks both alpha-1 and beta-adrenergic receptors, lowering blood pressure through a combination of reduced peripheral vascular resistance and decreased heart rate/cardiac output. It is FDA-approved for the management of hypertension and is frequently used in pregnancy-related hypertension due to its favorable safety profile. Labetalol should not be discontinued abruptly, as this can precipitate rebound hypertension or angina; doses should be tapered gradually under medical supervision. Common side effects include dizziness, fatigue, and orthostatic hypotension.
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