Olmesartan/HCTZ (Benicar HCT) is a combination angiotensin receptor blocker and diuretic used to treat high blood pressure.
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Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Olmesartan/hydrochlorothiazide (Benicar HCT) combines an angiotensin II receptor blocker (olmesartan), which relaxes blood vessels by blocking angiotensin II's vasoconstrictive effects, with a thiazide diuretic (hydrochlorothiazide), which reduces blood volume through increased sodium and water excretion. This combination provides complementary blood-pressure-lowering mechanisms for patients who are not adequately controlled on either agent alone. As with other ARBs, it carries a boxed warning against use during pregnancy due to the risk of fetal injury, and electrolyte and kidney function monitoring is recommended, particularly in patients with renal impairment.
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