Topical retinoid applied nightly to treat acne vulgaris.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Tretinoin (Retin-A, Retin-A Micro) is a topical retinoid available in cream (0.025%, 0.05%, 0.1%) and gel (0.01%, 0.025%) forms, indicated for acne vulgaris. Apply a pea-sized amount once daily at bedtime to clean, completely dry skin, waiting 20 to 30 minutes after washing before application. Avoid the eyes, mouth, and mucous membranes. Skin may become more sensitive to sunlight and wind, so patients should minimize sun exposure and use sunscreen. Common effects include redness, peeling, dryness, and stinging at the application site, which typically improve as the skin adjusts. These effects are reversible upon stopping treatment. Gel formulations are flammable and should be stored away from heat.
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Common side effects include redness, peeling, dryness, and a mild stinging or warming sensation at the application site, especially during the first few weeks of use. These effects are usually mild and reversible upon discontinuation.
Important warnings:
Use with caution alongside other topical acne products, as combined use may increase skin irritation.