Ursodiol (Actigall, Urso) is a bile acid medication used to dissolve certain gallstones and to treat primary biliary cholangitis.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Ursodiol (ursodeoxycholic acid) is a naturally occurring bile acid that reduces cholesterol saturation in bile, helping to dissolve cholesterol-based gallstones in patients who are not candidates for surgery, and also improves liver enzyme and bile flow abnormalities in primary biliary cholangitis. It is FDA-approved for the treatment of primary biliary cholangitis and for the dissolution of small to medium-sized cholesterol gallstones. Treatment for gallstone dissolution is typically prolonged (months), and periodic ultrasound monitoring is used to assess treatment response; ursodiol is not effective for calcified or pigmented gallstones.
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