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Prescription smoking cessation medication that reduces nicotine cravings and withdrawal symptoms to help adults quit smoking.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Varenicline (Chantix) is a prescription medication used to help adults quit smoking. It is a partial agonist at nicotinic acetylcholine receptors, meaning it binds to the same brain receptors that nicotine does. This helps relieve nicotine withdrawal symptoms and cravings while also reducing the pleasurable effects of nicotine if the patient continues to smoke or vape. Varenicline is typically started about one week before a chosen quit date, with a gradual dose increase over the first eight days, and is usually taken for 12 weeks, with an additional 12-week course sometimes recommended to help maintain abstinence. It should be taken with food and a full glass of water. Patients and caregivers should watch for any changes in mood or behavior while taking varenicline and should discuss their full medical and psychiatric history with a healthcare provider before starting treatment.
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Varenicline (Chantix) is a prescription medication approved to help adults stop smoking. It works as a partial agonist at the alpha4beta2 nicotinic acetylcholine receptor, the same receptor that nicotine stimulates in the brain. By partially activating this receptor, varenicline reduces the cravings and withdrawal symptoms that occur when a person stops using nicotine, and it also blocks nicotine from fully binding to the receptor, which reduces the satisfaction or reward a person feels if they smoke while taking the medication.
Patients typically begin varenicline about one week before their planned quit date, starting with a lower dose that is gradually increased over the first eight days of treatment. A full course usually lasts 12 weeks, and some patients who successfully quit may be prescribed an additional 12 weeks to help maintain abstinence. Varenicline works best when combined with a comprehensive smoking cessation program that includes counseling and behavioral support.