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Dihydroergotamine: Uses, Dosage, Side Effects, and More
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Dihydroergotamine Mesylate is a prescription ergot alkaloid used to treat acute migraine attacks, with or without aura, in adults. It works by constricting blood vessels around the brain and reducing inflammation of nerve pathways that cause migraine pain, nausea, and light or sound sensitivity. Available as a nasal spray or injection, it is used at migraine onset rather than for prevention.
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Controlled Substance Warning
Dihydroergotamine Mesylate is not a controlled substance. It must be used only as directed at the start of a migraine, not daily, to avoid rebound headaches. It should not be used within 24 hours of triptans or other ergot drugs and is contraindicated in patients with certain heart or liver conditions due to its vasoconstrictive effects.
Drug Facts
Generic Name
Dihydroergotamine Mesylate
Brand Names
Migranal
Drug Type
Ergot alkaloid (antimigraine agent)
Dosage Forms
Nasal spray, injectable solution
Typical Dosage
- Nasal spray: One spray (0.5 mg) into each nostril, repeated after 15 minutes if needed, for a total dose of up to 4 sprays (2 mg) per migraine attack.
- Injection (for healthcare or home use): 1 mg intravenously, intramuscularly, or subcutaneously; may repeat after one hour if necessary, not to exceed 2 mg per day or 6 mg per week.
- Dosing frequency should be individualized based on response and tolerance.
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Disclaimer
The information provided on this page is for general informational purposes only and is not intended as medical advice. Always consult with a licensed healthcare provider before starting, stopping, or changing any medication regimen. While Invictus strives to provide accurate and up-to-date information, individual health conditions and circumstances vary. The prices, availability, and descriptions of all medications on this page are subject to change.
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