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Divalproex: Uses, Dosage, Side Effects, and More
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Divalproex is a prescription anticonvulsant and mood stabilizer used to treat seizure disorders, bipolar disorder, and to prevent migraine headaches. It works by balancing neurotransmitters in the brain to control abnormal electrical activity and stabilize mood. When taken regularly, Depakote reduces seizure frequency, prevents manic episodes, and lessens migraine occurrence.
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Controlled Substance Warning
Divalproex is not a controlled substance. It must be taken exactly as prescribed and requires regular blood tests to monitor safe levels. Do not stop suddenly, as this can trigger seizures or symptom relapse. Rarely, Depakote can cause liver or pancreatic problems—seek immediate medical attention for abdominal pain, nausea, vomiting, or yellowing of the skin or eyes.
Drug Facts
Generic Name
Divalproex Sodium
Brand Names
Depakote, Depakote ER
Drug Type
Anticonvulsant/mood stabilizer
Dosage Forms
Tablets (delayed-release, extended-release), sprinkle capsules
Typical Dosage
- Epilepsy: Start with 10–15 mg/kg per day, increasing by 5–10 mg/kg per week as needed (usual range: 30–60 mg/kg daily).
- Bipolar disorder (mania): 750 mg per day in divided doses; adjusted to maintain therapeutic blood levels (50–125 mcg/mL).
- Migraine prevention: 250 mg twice daily; may be increased to 500 mg twice daily as needed.
- Doses should be individualized based on response, age, and medical condition.
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Disclaimer
The information provided on this page is for general informational purposes only and is not intended as medical advice. Always consult with a licensed healthcare provider before starting, stopping, or changing any medication regimen. While Invictus strives to provide accurate and up-to-date information, individual health conditions and circumstances vary. The prices, availability, and descriptions of all medications on this page are subject to change.
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