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Brivaracetam is an anticonvulsant used as adjunctive therapy for partial-onset (focal) seizures in patients with epilepsy.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Brivaracetam (Briviact) is an antiepileptic drug that binds to synaptic vesicle protein 2A (SV2A) in the brain, modulating neurotransmitter release to help control seizures. It is used as adjunctive (add-on) therapy for partial-onset seizures in patients 1 month of age and older, and is available as tablets, an oral solution, and an intravenous injection for when oral administration is not feasible. Typical starting dose is 50 mg twice daily, with adjustments made based on response and tolerability, up to a maximum of 200 mg per day. Common side effects include drowsiness, dizziness, fatigue, and nausea. Behavioral and psychiatric symptoms, including irritability, aggression, anxiety, or depression, have been reported, and should be discussed with a healthcare provider if they occur. As with other antiepileptic drugs, brivaracetam should not be stopped abruptly, as this can increase the risk of seizure recurrence or status epilepticus; the dose should be tapered gradually under medical supervision.
Brivaracetam is an antiepileptic medication used as adjunctive therapy for partial-onset seizures. It works by binding to synaptic vesicle protein 2A (SV2A) in the brain, which helps modulate the release of neurotransmitters and reduce seizure activity.
Common side effects include drowsiness, dizziness, fatigue, and nausea.
Behavioral and psychiatric effects such as irritability, aggression, anxiety, or depression have been reported and should be discussed with a healthcare provider if they occur.
Important: Do not stop brivaracetam abruptly. Sudden discontinuation can increase the risk of seizure recurrence or status epilepticus; the dose should be tapered gradually under medical supervision.