Nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation from osteoarthritis, rheumatoid arthritis, and acute pain.
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Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Etodolac inhibits cyclooxygenase (COX), reducing the synthesis of prostaglandins that cause pain, fever, and inflammation. It is used for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of acute pain, and is available in immediate-release tablets/capsules and extended-release tablets. Common side effects include stomach upset, heartburn, dizziness, and headache. Like other NSAIDs, etodolac carries a boxed warning for increased risk of serious cardiovascular thrombotic events (heart attack, stroke) and for serious, sometimes fatal, gastrointestinal bleeding, ulceration, and perforation; risk increases with duration of use, higher doses, and in patients with a history of GI disease. It should be used at the lowest effective dose for the shortest duration necessary, and is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.
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Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation by inhibiting cyclooxygenase (COX) enzymes and prostaglandin synthesis. It is used for osteoarthritis, rheumatoid arthritis, and acute pain.
Boxed Warning: NSAIDs, including etodolac, increase the risk of serious cardiovascular thrombotic events such as heart attack and stroke, which can be fatal; this risk may occur early in treatment and increases with duration of use. NSAIDs also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can occur without warning symptoms.
Common side effects include stomach upset, heartburn, dizziness, and headache.
Precautions: Etodolac is contraindicated in the setting of coronary artery bypass graft (CABG) surgery, and should be used with caution in patients with a history of GI disease, kidney impairment, or cardiovascular risk factors.