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Ibuprofen (Advil, Motrin) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce fever, and control inflammation.
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Dr. Steven Blikstein, PharmD
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Ibuprofen (Advil, Motrin) is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes to reduce the production of prostaglandins involved in pain, fever, and inflammation. It is used for a wide range of conditions including headache, muscle aches, arthritis, menstrual cramps, and fever. Ibuprofen carries an FDA boxed warning for increased risk of cardiovascular events (heart attack, stroke) and serious gastrointestinal bleeding, particularly with long-term or high-dose use, and should be used at the lowest effective dose for the shortest duration necessary.
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Amitriptyline is a prescription antidepressant used to treat major depressive disorder (MDD) and, in some cases, chronic pain, migraine prevention, and sleep disturbances. As a tricyclic antidepressant (TCA), it increases levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine. Amitriptyline helps improve mood, relieve anxiety and tension, and promote better sleep. It is available by prescription only and should be taken exactly as directed by a healthcare provider.
Intrathecal baclofen is a prescription muscle relaxant that reduces spasticity, stiffness, and muscle spasms caused by conditions such as multiple sclerosis, spinal cord injury, or cerebral palsy. It acts on the central nervous system to decrease excessive muscle contractions and is available in oral or intrathecal forms, depending on patient needs and symptom severity. Abruptly stopping treatment can cause severe withdrawal symptoms, so dosage changes must be made gradually under a physician’s direction.
A COX-2 inhibitor NSAID for arthritis and pain relief, with fewer stomach side effects than traditional NSAIDs.
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Cyclobenzaprine is a prescription muscle relaxant used to relieve muscle spasms and pain from acute musculoskeletal conditions such as strains or sprains. Acting on the central nervous system, it reduces muscle tension and improves mobility. Typically prescribed for short-term use, Cyclobenzaprine is often combined with rest and physical therapy for optimal recovery. Patients should avoid driving or operating machinery during the initial treatment period. Alcohol and other sedatives should be avoided, as they can increase drowsiness and side effects.
An NSAID used to relieve pain, swelling, and inflammation from arthritis and joint or muscle injuries.
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Dihydroergotamine mesylate is a prescription ergot alkaloid used to treat acute migraine attacks, with or without aura, in adults. It works by constricting blood vessels around the brain and reducing inflammation of nerve pathways that cause migraine pain, nausea, and light or sound sensitivity. Available as a nasal spray or injection, it is used at migraine onset rather than for prevention. Dihydroergotamine mesylate must be used only as directed at the start of a migraine, not daily, to avoid rebound headaches. It should not be used within 24 hours of triptans or other ergot drugs and is contraindicated in patients with certain heart or liver conditions.