Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Ozempic tablets are the FDA-approved oral formulation of semaglutide, a GLP-1 receptor agonist manufactured by Novo Nordisk. In the US, Ozempic tablets are the reformulated and renamed version of Rybelsus. They are available in 1.5 mg (starting dose), 4 mg, and 9 mg strengths. Along with diet and exercise, Ozempic tablets 4 mg and 9 mg are approved to improve blood sugar (glucose) control in adults with type 2 diabetes, and to reduce the risk of major cardiovascular events (heart attack, stroke, or death) in adults with type 2 diabetes who are at high risk for these events. Ozempic tablets are not approved for weight management; the FDA-approved oral semaglutide tablet for weight management is a separate product, the Wegovy pill. Semaglutide works by mimicking the GLP-1 hormone, which slows gastric emptying, increases feelings of fullness, and helps regulate blood sugar. Ozempic tablets should be taken once daily on an empty stomach with no more than 4 oz of plain water, swallowed whole (not split, crushed, or chewed), followed by waiting at least 30 minutes before eating, drinking, or taking other oral medications. Common side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain. Ozempic tablets carry a boxed warning against use in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, based on thyroid C-cell tumors observed in animal studies. Rare but serious risks include pancreatitis and gallbladder problems. Patients should discuss the risks and benefits with their healthcare provider.
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FDA-approved brand-name medication: Ozempic tablets are the FDA-approved oral form of semaglutide, manufactured by Novo Nordisk. This is the brand-name product, not a compounded medication. In the US, Ozempic tablets are the reformulated and renamed version of Rybelsus, and they are available in 1.5 mg, 4 mg, and 9 mg strengths.
What it is approved for: Along with diet and exercise, Ozempic tablets 4 mg and 9 mg are approved to improve blood sugar control in adults with type 2 diabetes, and to reduce the risk of major cardiovascular events (heart attack, stroke, or death) in adults with type 2 diabetes who are at high risk for these events. The 1.5 mg tablet is the starting dose. Ozempic tablets are not approved for weight management and are not approved for use in children.
How to take it: Take one tablet once daily on an empty stomach with no more than 4 ounces of plain water. Swallow it whole (do not split, crush, or chew), then wait at least 30 minutes before eating, drinking anything else, or taking other oral medications.
Common side effects:
Nausea, vomiting, or diarrhea
Constipation
Abdominal pain
Boxed warning: Ozempic tablets may cause thyroid tumors, including cancer. Do not use Ozempic tablets if you or a family member has ever had medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Currently taking Rybelsus? Keep taking your medication as prescribed and talk to your prescriber before switching to Ozempic tablets.