NEW2026 · Text us +1 272-529-4722
A once-daily tablet that helps prevent asthma symptoms and relieve seasonal allergies.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
Form
Strength
How would you like to get this medication?
Choose a strength and quantity to continue.
Montelukast (Singulair) is a prescription leukotriene receptor antagonist used to prevent and control asthma symptoms and to relieve seasonal and year-round allergic rhinitis; it is also used to prevent exercise-induced bronchoconstriction. It works by blocking leukotrienes, inflammatory chemicals that cause airway swelling, mucus production, and bronchoconstriction. For asthma and allergic rhinitis, it is usually taken once daily in the evening, with dosing based on age (10 mg for adults and adolescents 15 and older, a 4 mg or 5 mg chewable tablet for younger children per product labeling). For exercise-induced bronchoconstriction, a single dose is taken at least 2 hours before activity. Montelukast is a maintenance medicine, not a rescue inhaler, and does not relieve a sudden asthma attack already in progress. The FDA has issued a boxed warning that montelukast has been associated with serious neuropsychiatric events, including agitation, aggression, anxiety, depression, sleep disturbances (including nightmares), hallucinations, and suicidal thoughts or actions; patients and caregivers should watch for behavior or mood changes and seek medical care right away if they occur. Because of this risk, montelukast is generally reserved for allergic rhinitis only in patients who cannot tolerate or do not respond to other therapies. Other side effects can include headache, stomach pain, and upper respiratory infection symptoms. Patients should not stop or reduce other asthma medications, including inhaled corticosteroids, without their provider's guidance, even if symptoms improve.
Complete a health screening
A short questionnaire about your health history and current symptoms — takes about 2 minutes.
Book a video visit
Schedule a brief video call with a licensed provider at a time that works for you.
Attend your video visit
A licensed provider conducts the video visit and issues your prescription if appropriate.
Prescription fulfilled
If approved, your Rx is sent to Invictus Pharmacy and you're notified by text or email. Free nationwide shipping.
Important safety information
Careful assessment of contraindications is essential to ensure that Singulair (montelukast) is prescribed safely and appropriately. Identifying patients for whom the medication may pose increased risks helps prevent avoidable adverse effects while maximizing therapeutic benefit.
Both absolute contraindications and important precautions should be considered before and during treatment.
By reviewing contraindications and implementing appropriate precautions, healthcare providers can ensure that Singulair is used in a manner that balances effectiveness with patient safety. Patients, caregivers, and clinicians should closely monitor for new or worsening mood or behavioral changes, particularly after initiating therapy or adjusting the dose.
Prescription nasal spray combining an antihistamine and a corticosteroid, used twice daily to relieve symptoms of seasonal allergic rhinitis in patients 6 years and older.
Antihistamine nasal spray used to relieve sneezing, runny nose, and itchy nose caused by seasonal or year-round allergies (and, for some strengths, non-allergic/vasomotor rhinitis).
A non-narcotic prescription cough suppressant that numbs the airways to reduce coughing.
Video visit required
A COX-2 inhibitor NSAID for arthritis and pain relief, with fewer stomach side effects than traditional NSAIDs.
Video visit required
An NSAID used to relieve pain, swelling, and inflammation from arthritis and joint or muscle injuries.
Video visit required
A proton pump inhibitor that reduces stomach acid to treat GERD, ulcers, and heartburn.
Video visit required
Montelukast is the generic form of Singulair, ensuring a more affordable option for those requiring long-term treatment for asthma and allergies. Like its brand-name counterpart, montelukast shares the exact mechanism of action and efficacy profile.
As a leukotriene receptor antagonist, it provides similar benefits by reducing airway swelling, lessening mucus production, and preventing exercise-induced bronchoconstriction. Montelukast is indicated for both pediatric and adult populations and can be dosed according to age and specific needs.
Note: This medication’s generic and brand-name formulations are used interchangeably throughout this article.
Singulair is a brand-name medication used to manage and prevent asthma symptoms and allergic rhinitis. It is part of the leukotriene receptor antagonist class, which helps alleviate airway inflammation and mitigate allergic symptoms.
Singulair is often prescribed to individuals who struggle with persistent asthma and allergic rhinitis, providing a non-steroidal alternative in respiratory therapy.
Singulair’s effectiveness stems from its ability to block leukotrienes, the substances in your body that cause asthma and allergy symptoms. It is particularly favored for its specificity in targeting these pathways, making it a valuable addition to asthma management plans.
Singulair is utilized for several conditions related to respiratory health and allergies, with specific indications and some off-label uses. Its ability to block leukotrienes provides relief from inflammation and bronchoconstriction, making it a versatile medication.
Singulair’s action in the body centers on its ability to inhibit the effects of these mediators, thereby providing relief from asthma and allergy symptoms. Understanding its mechanism and pharmacokinetics can help patients grasp how it facilitates breathing and reduces inflammation.
Montelukast works by binding to leukotriene receptors in the lungs and nasal passages. Leukotrienes are inflammatory mediators released in response to allergens and contribute to asthma symptoms, including airway edema, smooth muscle constriction, and mucus production.
By blocking these receptors, montelukast reduces inflammation and prevents bronchoconstriction, thus helping to keep airways open.
Proper dosing and administration are vital for maximizing Singulair’s effectiveness while minimizing potential side effects. Understanding how to take this medication correctly can significantly affect treatment outcomes.
Singulair can be ingested with or without meals, providing flexibility for patients. It is generally recommended to take it at the same time each day, often in the evening, to align with the body’s circadian rhythm, when asthma symptoms are typically more active.
Consistency in timing helps maintain stable blood levels of the medication, thereby enhancing its preventive efficacy.
While Singulair is generally well-tolerated and widely used for asthma and allergy management, patients and caregivers should be aware of its potential side effects.
Awareness of both common and serious reactions helps ensure early recognition of adverse effects and timely medical intervention when necessary.
Common side effects are typically mild and transient, often improving as the body adjusts to the medication:
Although uncommon, serious side effects require prompt medical attention and careful evaluation:
Maintaining awareness of drug interactions is essential for safe and effective medication use. Singulair has known interactions that may affect its efficacy.
Administration & Dosage
Montelukast is typically taken once daily in the evening. This timing is chosen to better manage nighttime symptoms associated with asthma and allergies. Taking it at night aligns the medication with the body's nocturnal rhythm, thereby improving symptom control.
Although montelukast is generally recommended for evening use, it can be taken in the morning if your doctor prescribes it. The timing should consistently follow your physician's guidance to maintain optimal symptom control.
Montelukast has a half-life that supports once-daily dosing, with its effects lasting approximately 24 hours. This duration allows the medication to sustain its therapeutic effect throughout the day and night, providing continuous symptom management.
Discontinuing montelukast suddenly is not advised without consulting your doctor—abrupt cessation may precipitate a return of asthma or allergy symptoms. A healthcare provider can guide you on the appropriate method for adjusting or discontinuing the medication.
Montelukast is not commonly associated with drowsiness. It is not classified as sedating. However, because individuals respond differently to medications, if unusual fatigue occurs, it's essential to consult a healthcare provider to address any concerns.
Uses & Mechanism of Action
Montelukast is used to prevent asthma attacks and to relieve symptoms of allergic rhinitis, such as sneezing, a runny nose, and itching. It helps manage these conditions by targeting specific pathways in the allergic response, thereby supporting better respiratory health.
Montelukast works by blocking leukotrienes, chemicals released during allergic reactions. By inhibiting these substances, the medication reduces airway inflammation, swelling, and mucus production, thereby relieving asthma and allergy symptoms.
Montelukast is not an antihistamine. It is a leukotriene receptor antagonist, meaning it acts on distinct chemical pathways from antihistamines. While both address allergy symptoms, they do so through different mechanisms that complement one another.
Montelukast is effective in managing allergy symptoms, particularly allergic rhinitis. It helps control sneezing, nasal congestion, and other allergic symptoms by dampening the chemical signals that trigger inflammation and allergic responses.
Montelukast is not a bronchodilator. Rather than directly relaxing airway muscles, it focuses on reducing inflammation. This anti-inflammatory effect complements bronchodilators, which open airways to improve airflow in patients with asthma.
Side Effects & Safety
Common side effects of montelukast include headache, abdominal pain, and sore throat. Although these are usually mild, profound effects, such as mood change, should be monitored. Contact a healthcare professional if you experience severe or unusual symptoms.
Weight gain is not typically associated with montelukast use. If you notice significant weight changes while taking the medication, it is essential to discuss this with your healthcare provider to rule out other potential causes or medication adjustments.
Mood changes, including depression, have been reported by some individuals taking montelukast. It is crucial to be vigilant for these symptoms and to consult a healthcare provider promptly if you or someone around you notices any notable mood changes.
Montelukast is not commonly linked to increased blood pressure. Patients with hypertension or those concerned about blood pressure changes should speak with their healthcare provider to ensure that montelukast is safe, given their specific health circumstances.
Montelukast should be used during pregnancy only if necessary and prescribed by a healthcare provider. Discussing potential risks and benefits with your physician is essential for making informed decisions about the management of asthma or allergies during pregnancy.
Interactions & Contraindications
There are no known adverse interactions between montelukast and Benadryl, allowing their coadministration if needed. However, it is always advisable to consult with a healthcare provider before combining medications to ensure personal safety and efficacy.
Montelukast does not require specific dietary or activity restrictions. However, following all guidance from your healthcare provider regarding medication management, lifestyle choices, and any individual precautions is essential for optimal therapeutic outcomes.
Montelukast and Zyrtec can generally be taken together, as their mechanisms complement each other. While Zyrtec is an antihistamine and montelukast is a leukotriene receptor antagonist, consulting a healthcare provider ensures that this combination meets individual health needs.
Montelukast is not classified as a controlled substance. It is a readily available prescription for the management of asthma and allergic symptoms. This classification reflects its lack of potential for abuse or dependency, focusing purely on therapeutic use.
Montelukast is not officially approved for veterinary use. If considering its use in pets, it is critical to consult a veterinarian who can guide appropriate treatments and dosages tailored to the animal's specific health requirements.
Generic & Alternatives
Montelukast is the generic form of the brand-name drug Singulair, which is frequently used to manage chronic conditions such as asthma and allergic rhinitis. The generic version offers a cost-effective alternative with the same therapeutic benefits and efficacy as Singulair.
Montelukast is the generic equivalent of Singulair. Both contain the same active ingredient and are equivalent in efficacy for treating asthma and allergic symptoms, thereby providing flexibility in brand selection and cost.
Montelukast is available only by prescription. It requires a healthcare provider's oversight to ensure its suitability and safety for the patient's specific medical condition and to ensure appropriate use in managing asthma and allergy symptoms effectively.
Alternatives to montelukast include other leukotriene receptor antagonists or inhaled corticosteroids. The choice of medication should be guided by a healthcare provider, who will consider individual patient needs and medical history when recommending suitable options.
Montelukast remains widely available and has not been discontinued. It is available under various brand names, including Singulair, providing ongoing therapeutic options for individuals managing asthma and allergic symptoms.
Montelukast may begin to take effect within 1 day, although full benefit may take several weeks to manifest. Consistent daily use is key to achieving maximum symptom control, especially when addressing chronic conditions like asthma and allergies.