Combination topical gel that pairs an antibiotic with benzoyl peroxide to treat acne vulgaris.
Reviewed by:
Dr. Steve Malen, PharmD
Dr. Steven Blikstein, PharmD
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Clindamycin phosphate 1% / benzoyl peroxide 5% gel is a prescription combination product for acne vulgaris. Clindamycin is a lincosamide antibiotic that reduces acne-causing bacteria (C. acnes) and inflammation; benzoyl peroxide is a keratolytic and antibacterial agent that helps unclog pores and limits antibiotic resistance. Apply a thin layer to affected areas once or twice daily after gently washing and drying the skin. Common effects include dryness, peeling, and mild irritation. Because topical clindamycin is absorbed systemically, rare but serious diarrhea/colitis has been reported — discontinue and contact a provider if severe or persistent diarrhea occurs. Avoid eyes, lips, and mucous membranes; product may bleach hair and colored fabric.
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Most common: dry skin, mild burning/stinging, redness, and peeling at the application site (up to ~12% of patients).
Important safety information: Topical clindamycin is absorbed into the bloodstream and, rarely, has been associated with severe diarrhea or colitis (including C. difficile-associated colitis) even weeks after stopping treatment. Stop use and contact your provider if severe, persistent, or bloody diarrhea occurs.
Avoid contact with eyes, lips, mouth, and mucous membranes. May bleach hair, clothing, and colored fabrics. Not for use in patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis, or with hypersensitivity to clindamycin, lincomycin, or benzoyl peroxide.