Estradiol is a prescription estrogen hormone used to treat menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. It also helps prevent osteoporosis, correct hormonal imbalances, and support estrogen replacement therapy. By supplementing declining estrogen levels, estradiol helps maintain reproductive tissue, bone, and cardiovascular health. It is available as oral tablets, vaginal cream, and topical forms based on treatment needs. Estradiol must be used exactly as prescribed, at the lowest effective dose for the shortest time necessary. Estrogen therapy may increase the risk of blood clots, stroke, heart attack, or certain cancers, so regular medical monitoring is essential.