Dihydroergotamine Mesylate
Ergot alkaloid (antimigraine agent)
Dihydroergotamine mesylate is a prescription ergot alkaloid used to treat acute migraine attacks, with or without aura, in adults. It works by constricting blood vessels around the brain and reducing inflammation of nerve pathways that cause migraine pain, nausea, and light or sound sensitivity. Available as a nasal spray or injection, it is used at migraine onset rather than for prevention. Dihydroergotamine mesylate must be used only as directed at the start of a migraine, not daily, to avoid rebound headaches. It should not be used within 24 hours of triptans or other ergot drugs and is contraindicated in patients with certain heart or liver conditions.