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Premarin (conjugated estrogens) is an estrogen hormone medication available as oral tablets and vaginal cream. It is used to treat moderate-to-severe hot flashes and vaginal dryness/atrophy associated with menopause, to treat certain causes of low estrogen (hypoestrogenism), and to help prevent postmenopausal osteoporosis. In women with a uterus, it is typically combined with a progestin to reduce the risk of endometrial cancer.

Prempro is a combination oral tablet containing conjugated estrogens and medroxyprogesterone acetate (a progestin), used to treat moderate-to-severe hot flashes and vaginal changes of menopause and to help prevent postmenopausal osteoporosis in women with an intact uterus. The added progestin lowers the risk of endometrial cancer associated with estrogen-only therapy.