Clomiphene Citrate
Fertility
Clomiphene citrate is a powerful, nonsteroidal Selective Estrogen Receptor Modulator (SERM) used as a first-line, orally administered therapy for treating ovulatory dysfunction in women desiring pregnancy. It works by selectively modulating estrogen receptors to stimulate the hypothalamic–pituitary–ovarian (HPO) axis, leading to follicular growth and subsequent ovulation. Since its FDA approval in 1967, it has been widely used and is also employed off-label in men with secondary hypogonadism.